Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GUSB | P08236 | 2/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 5/20 | 0.41 |
| ▸ | HTR1D | P28221 | 3/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | HTR1B | P28222 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1776483 | 0.99 | IDH2 (0.43) | IDH2MAPTKMT2AGUSBADRB1 | |
| SCHEMBL1776192 | 0.88 | HTR2C (0.40) | GUSBADRB1HTR6HTR1DHTR1A | |
| Hydrochloric Acid SCHEMBL1774117 | 0.88 | HTR2C (0.39) | GUSBADRB1HTR6HTR1DHTR1A | |
| SCHEMBL1777202 | 0.86 | HTR6 (0.48) | GUSBHTR6HTR1DHTR1AHTR1B | |
| Hydrochloric Acid SCHEMBL1775919 | 0.86 | HTR6 (0.47) | GUSBHTR6HTR1DHTR1AHTR1B | |
| SCHEMBL1775934 | 0.84 | HTR6 (0.44) | MAPTKMT2AGUSBMEN1HTR6 | |
| Hydrochloric Acid SCHEMBL1774686 | 0.83 | HTR6 (0.44) | MAPTKMT2AGUSBMEN1HTR6 | |
| SCHEMBL1776158 | 0.82 | HTR6 (0.54) | GUSBHTR6HTR1DHTR1AHTR1B | |
| Hydrochloric Acid SCHEMBL1776342 | 0.81 | HTR6 (0.53) | GUSBHTR6HTR1DHTR1AHTR1B | |
| SCHEMBL1775636 | 0.81 | HTR6 (0.47) | GUSBHTR6HTR1DHTR1AHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943639-B2 | Such as 6-benzenesulfonyl-4-piperazin-1-yl-quinoline hydrochloride; for treatment of central nervous system and/or 5- HT6 receptor related disorders; for weight gain/loss | PROXIMAGEN LIMITED (GB) | 2011-05-17 | — | — | US | claimed |