Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GLB1 | P16278 | 1/20 | 0.35 |
| ▸ | GUSB | P08236 | 2/20 | 0.33 |
| ▸ | GBA1 | P04062 | 2/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27067618 | 1.00 | SMN1; SMN2 (0.38) | SMN1; SMN2GLB1GUSBGBA1HSD11B1 | |
| SCHEMBL23707055 | 1.00 | SMN1; SMN2 (0.38) | SMN1; SMN2GLB1GUSBGBA1HSD11B1 | |
| SCHEMBL21146446 | 0.88 | CYP3A4 (0.38) | SMN1; SMN2GLB1GUSBHSD11B1CYP3A4 | |
| SCHEMBL1893625 | 0.83 | SMN1; SMN2 (0.38) | SMN1; SMN2GLB1GBA1HSD11B1 | |
| SCHEMBL23425750 | 0.83 | SMN1; SMN2 (0.38) | SMN1; SMN2GLB1GBA1HSD11B1 | |
| SCHEMBL1893624 | 0.83 | SMN1; SMN2 (0.38) | SMN1; SMN2GLB1GBA1HSD11B1 | |
| SCHEMBL1893627 | 0.83 | SMN1; SMN2 (0.38) | SMN1; SMN2GLB1GBA1HSD11B1 | |
| SCHEMBL15317974 | 0.80 | — | — | |
| SCHEMBL23475172 | 0.80 | SMN1; SMN2 (0.42) | SMN1; SMN2GLB1GUSBGBA1HSD11B1 | |
| SCHEMBL9090010 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210087189-A1 | SUBSTITUTED ISINDOLIN-1-ONES AND 2,3-DIHYDRO-1H-PYRROLO[3,3-c]PYRIDIN-1-ONES AS HPK1 ANTAGONISTS | CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED (GB) | 2021-03-25 | — | — | US | disclosed |
| US-20210078997-A1 | SUBSTITUTED ISOINDOLIN-1-ONES AND 2,3-DIHYDRO-1H-PYRROL[3,4-c]PYRIDIN-1-ONES AS HPK1 ANTAGONISTS | CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED (GB) | 2021-03-18 | — | — | US | disclosed |
| WO-2016081679-A1 | HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2016-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210078997-A1 | SUBSTITUTED ISOINDOLIN-1-ONES AND 2,3-DIHYDRO-1H-PYRROL[3,4-c]PYRIDIN-1-ONES AS HPK1 ANTAGONISTS | HIPK1, PDXK, IP6K1 | SMN1; SMN2 2709/4885GLB1 3733/4885GUSB 4715/4885 |
| US-20210087189-A1 | SUBSTITUTED ISINDOLIN-1-ONES AND 2,3-DIHYDRO-1H-PYRROLO[3,3-c]PYRIDIN-1-ONES AS HPK1 ANTAGONISTS | HIPK1, PDXK, SIK1 | SMN1; SMN2 2011/4885GLB1 4379/4885GUSB 4830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.