Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LPL | P06858 | 1/20 | 0.36 |
| ▸ | LIPC | P11150 | 1/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19669097 | 1.00 | TRPV1 (0.42) | TRPV1MAP4K4PDE10ADGAT2MAP3K12 | |
| SCHEMBL16754579 | 1.00 | TRPV1 (0.42) | TRPV1MAP4K4PDE10ADGAT2MAP3K12 | |
| SCHEMBL16754431 | 1.00 | TRPV1 (0.42) | TRPV1MAP4K4PDE10ADGAT2MAP3K12 | |
| SCHEMBL16754642 | 1.00 | TRPV1 (0.42) | TRPV1MAP4K4PDE10ADGAT2MAP3K12 | |
| SCHEMBL16754535 | 0.96 | TRPV1 (0.42) | TRPV1MAP4K4PDE10ADGAT2MAP3K12 | |
| SCHEMBL17778529 | 0.96 | DGAT2 (0.41) | TRPV1MAP4K4PDE10ADGAT2MAP3K12 | |
| SCHEMBL16754489 | 0.96 | DGAT2 (0.41) | TRPV1MAP4K4PDE10ADGAT2MAP3K12 | |
| SCHEMBL16754580 | 0.96 | DGAT2 (0.41) | TRPV1MAP4K4PDE10ADGAT2MAP3K12 | |
| SCHEMBL16754341 | 0.96 | MAP4K4 (0.42) | TRPV1MAP4K4PDE10ADGAT2TRPV3 | |
| SCHEMBL16754343 | 0.96 | MAP4K4 (0.42) | TRPV1MAP4K4PDE10ADGAT2TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016081692-A2 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-05-26 | — | — | WO | disclosed |