Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 6/20 | 0.46 |
| ▸ | TRPV3 | Q8NET8 | 3/20 | 0.40 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16754566 | 1.00 | MAP4K4 (0.46) | MAP4K4TRPV3EIF2AK4PDE10APSEN1 | |
| SCHEMBL16237499 | 0.96 | MAP4K4 (0.49) | MAP4K4TRPV3EIF2AK4PDE10APSEN1 | |
| SCHEMBL20632886 | 0.96 | MAP4K4 (0.49) | MAP4K4TRPV3EIF2AK4PDE10APSEN1 | |
| SCHEMBL16249992 | 0.96 | MAP4K4 (0.49) | MAP4K4TRPV3EIF2AK4PDE10APSEN1 | |
| SCHEMBL17778379 | 0.96 | MAP4K4 (0.49) | MAP4K4TRPV3EIF2AK4PDE10APSEN1 | |
| SCHEMBL16754630 | 0.94 | MAP4K4 (0.47) | MAP4K4TRPV3EIF2AK4PDE10AHRH3 | |
| SCHEMBL17618336 | 0.89 | MAP4K4 (0.49) | MAP4K4TRPV3EIF2AK4PDE10APSEN1 | |
| SCHEMBL19670116 | 0.84 | CASP1 (0.34) | MAP4K4PDE10ADGAT2HRH3 | |
| SCHEMBL16776499 | 0.82 | MAP4K4 (0.45) | MAP4K4TRPV3EIF2AK4PDE10APSEN1 | |
| SCHEMBL16776503 | 0.82 | MAP4K4 (0.45) | MAP4K4TRPV3EIF2AK4PDE10APSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016079711-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |