Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 12/20 | 0.35 |
| ▸ | CLK2 | P49760 | 11/20 | 0.35 |
| ▸ | CLK3 | P49761 | 11/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19706797 | 0.89 | JAK3 (0.37) | JAK3ROCK1CDC42BPB | |
| SCHEMBL19689803 | 0.89 | JAK3 (0.37) | JAK3ROCK1CDC42BPB | |
| SCHEMBL19689724 | 0.87 | RAF1 (0.35) | DYRK1ACLK2CLK3CYP1A2HTR2A | |
| SCHEMBL19706746 | 0.87 | RAF1 (0.35) | DYRK1ACLK2CLK3CYP1A2HTR2A | |
| SCHEMBL16754293 | 0.86 | PRMT5 (0.38) | WNT3AKIT | |
| SCHEMBL17770596 | 0.86 | PRMT5 (0.38) | WNT3AKIT | |
| SCHEMBL17618520 | 0.85 | USP30 (0.37) | DYRK1AROCK1CDC42BPBWNT3A | |
| SCHEMBL17767975 | 0.85 | WNT3A (0.35) | DYRK1ACLK2CLK3JAK3WNT3A | |
| SCHEMBL16754500 | 0.85 | IRAK4 (0.37) | JAK3WNT3AKIT | |
| SCHEMBL19706754 | 0.85 | DYRK1A (0.39) | DYRK1ACLK2CLK3CYP1A2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016079709-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |