Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 9/20 | 0.40 |
| ▸ | HTR2C | P28335 | 9/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.38 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | ACACB | O00763 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19689818 | 1.00 | HTR2A (0.40) | HTR2AHTR2CUSP30CACNA1GCACNA1H | |
| SCHEMBL17768124 | 0.93 | HTR2A (0.41) | HTR2AHTR2CCYP1A2 | |
| SCHEMBL17767930 | 0.92 | HTR2A (0.39) | HTR2AHTR2CCACNA1GCACNA1HCACNA1I | |
| SCHEMBL19689779 | 0.91 | HTR2C (0.43) | HTR2AHTR2CHTR2B | |
| SCHEMBL17767966 | 0.91 | HTR2A (0.43) | HTR2AHTR2CCYP1A2 | |
| SCHEMBL17778764 | 0.91 | HTR2A (0.43) | HTR2AHTR2CCYP1A2 | |
| SCHEMBL17778603 | 0.88 | ALDH1A1 (0.40) | HTR2AHTR2CMAPTMAPK1KMT2A | |
| SCHEMBL19689778 | 0.87 | HTR2C (0.41) | HTR2AHTR2CCYP1A2MAPTHTR2B | |
| SCHEMBL17778460 | 0.87 | MTOR (0.42) | HTR2AHTR2CCYP1A2MAPT | |
| SCHEMBL17778392 | 0.87 | HTR2A (0.37) | HTR2AHTR2CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016079709-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |