Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 15/20 | 0.48 |
| ▸ | HTR2A | P28223 | 14/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17768200 | 1.00 | HTR2C (0.48) | HTR2CHTR2ATRPV1GRIN2BPI4KB | |
| SCHEMBL16249988 | 1.00 | HTR2C (0.48) | HTR2CHTR2ATRPV1GRIN2BPI4KB | |
| SCHEMBL17770242 | 0.87 | HTR2C (0.42) | HTR2CHTR2ATRPV1GRIN2BPI4KB | |
| SCHEMBL22239519 | 0.87 | HTR2C (0.42) | HTR2CHTR2ATRPV1GRIN2BPI4KB | |
| SCHEMBL16754487 | 0.87 | JAK1 (0.38) | HTR2CHTR2A | |
| SCHEMBL17778684 | 0.87 | JAK1 (0.38) | HTR2CHTR2A | |
| SCHEMBL17778683 | 0.85 | HTR2A (0.44) | HTR2CHTR2ATRPV1 | |
| SCHEMBL17767906 | 0.85 | HTR2A (0.44) | HTR2CHTR2ATRPV1 | |
| SCHEMBL17778705 | 0.85 | HTR2A (0.44) | HTR2CHTR2ATRPV1 | |
| SCHEMBL17618428 | 0.85 | TSHR (0.46) | HTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016079709-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |