Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8427120 | 0.81 | KMT2A (0.47) | CYP1A2CYP3A4CYP2C19KMT2AHPGD | |
| SCHEMBL38661825 | 0.79 | CYP1A2 (0.44) | CYP1A2CYP3A4CYP2C19KMT2AHPGD | |
| SCHEMBL10459325 | 0.79 | CYP1A2 (0.48) | CYP1A2CYP3A4CYP2C19KMT2AHPGD | |
| SCHEMBL27906036 | 0.79 | CYP1A2 (0.44) | CYP1A2CYP3A4CYP2C19KMT2AHPGD | |
| SCHEMBL18337425 | 0.78 | CYP1A2 (0.54) | CYP1A2CYP3A4CYP2C19KMT2AHPGD | |
| SCHEMBL769495 | 0.78 | CYP1A2 (0.61) | CYP1A2CYP3A4CYP2C19KMT2AHPGD | |
| SCHEMBL7917526 | 0.78 | CYP1A2 (0.43) | CYP1A2CYP3A4CYP2C19KMT2AHPGD | |
| SCHEMBL29837917 | 0.78 | CYP1A2 (0.43) | CYP1A2CYP3A4CYP2C19KMT2AHPGD | |
| SCHEMBL7916612 | 0.78 | CYP1A2 (0.43) | CYP1A2CYP3A4CYP2C19KMT2AHPGD | |
| SCHEMBL29439711 | 0.78 | CYP1A2 (0.54) | CYP1A2CYP3A4CYP2C19KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016079709-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |