Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12603486 | 1.00 | MAPT (0.48) | MAPTMAPK1HTTSMN1; SMN2NR1H3 | |
| SCHEMBL1779177 | 0.90 | MAPT (0.49) | MAPTMAPK1HTTSMN1; SMN2NR1H3 | |
| SCHEMBL4589422 | 0.87 | MAPT (0.47) | MAPTMAPK1HTTSMN1; SMN2RAB9A | |
| SCHEMBL4589420 | 0.87 | MAPT (0.47) | MAPTMAPK1HTTSMN1; SMN2RAB9A | |
| SCHEMBL1777754 | 0.86 | MAPT (0.54) | MAPTMAPK1HTTSMN1; SMN2NR1H3 | |
| SCHEMBL1779447 | 0.86 | MAPT (0.54) | MAPTMAPK1HTTSMN1; SMN2NR1H3 | |
| SCHEMBL12603493 | 0.83 | MAPT (0.50) | MAPTMAPK1HTTSMN1; SMN2NR1H3 | |
| SCHEMBL4650314 | 0.83 | MAPT (0.48) | MAPTMAPK1HTTSMN1; SMN2RAB9A | |
| SCHEMBL12603492 | 0.83 | MAPT (0.50) | MAPTMAPK1HTTSMN1; SMN2NR1H3 | |
| SCHEMBL12603512 | 0.81 | MAPT (0.48) | MAPTMAPK1HTTSMN1; SMN2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943768-B2 | Piperazine compounds useful as antagonists of C-C chemokines (Ccr2b and CcrS) for the treatment of inflammatory diseases | ASTRAZENECA AB (SE) | 2011-05-17 | — | — | US | disclosed |