Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VRK1 | Q99986 | 16/20 | 0.53 |
| ▸ | RPS6KA3 | P51812 | 6/20 | 0.53 |
| ▸ | VRK2 | Q86Y07 | 2/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.53 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.53 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.53 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17780349 | 0.89 | VRK1 (0.68) | VRK1RPS6KA3VRK2JAK2BRD4 | |
| SCHEMBL17780339 | 0.88 | VRK1 (0.56) | VRK1RPS6KA3VRK2JAK2BRD4 | |
| SCHEMBL17780545 | 0.87 | VRK1 (0.51) | VRK1RPS6KA3VRK2JAK2BRD4 | |
| SCHEMBL17780578 | 0.86 | VRK1 (0.50) | VRK1RPS6KA3VRK2JAK2BRD4 | |
| SCHEMBL17780354 | 0.86 | VRK1 (0.50) | VRK1RPS6KA3VRK2JAK2BRD4 | |
| SCHEMBL17780534 | 0.85 | VRK1 (0.54) | VRK1RPS6KA3VRK2JAK2BRD4 | |
| SCHEMBL17780326 | 0.85 | VRK1 (0.38) | VRK1 | |
| SCHEMBL17780448 | 0.84 | VRK1 (0.37) | VRK1RPS6KA3VRK2JAK2BRD4 | |
| SCHEMBL17780596 | 0.84 | BRD4 (0.39) | VRK1BRD4 | |
| SCHEMBL17780559 | 0.83 | VRK1 (0.37) | VRK1BRD4RPS6KA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9351974-B2 | Substituted pteridinones for the treatment of cancer | OSI Pharmaceuticals, LLC (US) | 2016-05-31 | — | — | US | claimed |