Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13763261 | 0.91 | CA1 (0.39) | CYP3A4ACHEHPGDPOLBNOTUM | |
| SCHEMBL9542624 | 0.87 | CYP3A4 (0.53) | CYP3A4ACHEHPGDPOLBGLO1 | |
| SCHEMBL25747053 | 0.86 | NOTUM (0.49) | CYP3A4ACHEHPGDPOLBGLO1 | |
| SCHEMBL18130728 | 0.83 | NOTUM (0.40) | CYP3A4ACHEPOLBNOTUMALDH1A1 | |
| SCHEMBL17781486 | 0.80 | RXRB (0.44) | CYP3A4ACHEPOLBALDH1A1KDM4E | |
| SCHEMBL17831139 | 0.80 | CYP3A4 (0.50) | CYP3A4ACHEHPGDPOLBGLO1 | |
| SCHEMBL14696545 | 0.79 | POLB (0.41) | HPGDPOLBALDH1A1L3MBTL1TSHR | |
| SCHEMBL14696539 | 0.78 | POLB (0.45) | HPGDPOLBALDH1A1GAATSHR | |
| SCHEMBL22996828 | 0.77 | CYP3A4 (0.47) | CYP3A4ACHEHPGDPOLBGLO1 | |
| SCHEMBL17419113 | 0.77 | CYP3A4 (0.47) | CYP3A4ACHEHPGDPOLBGLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3280419-B1 | INDAZOLE AND AZAINDAZOLE BTK INHIBITORS | MERCK SHARP & DOHME (US) | 2019-10-30 | — | — | EP | disclosed |
| US-10246457-B2 | Indazole and azaindazole Btk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2019-04-02 | — | — | US | disclosed |
| EP-3026050-B1 | NOVEL TRIAZINE DERIVATIVE | CARNA BIOSCIENCES INC (JP) | 2018-11-07 | — | — | EP | disclosed |
| US-20180127411-A1 | INDAZOLE AND AZAINDAZOLE BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-05-10 | — | — | US | disclosed |
| EP-3280419-A1 | INDAZOLE AND AZAINDAZOLE BTK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2018-02-14 | — | — | EP | disclosed |
| US-9656995-B2 | Triazine derivative | CARNA BIOSCIENCES, INC. (JP) | 2017-05-23 | — | — | US | disclosed |
| WO-2016164285-A1 | INDAZOLE AND AZAINDAZOLE BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-10-13 | — | — | WO | disclosed |
| WO-2016161571-A1 | INDAZOLE AND AZAINDAZOLE BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-10-13 | — | — | WO | disclosed |
| US-20160168122-A1 | NOVEL TRIAZINE DERIVATIVE | CARNA BIOSCIENCES, INC. (JP) | 2016-06-16 | — | — | US | disclosed |
| EP-3026050-A1 | NOVEL TRIAZINE DERIVATIVE | Carna Biosciences Inc. (JP) | 2016-06-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127411-A1 | INDAZOLE AND AZAINDAZOLE BTK INHIBITORS | BTK, SYK, ABL1 | CYP3A4 1319/4885ACHE 2310/4885HPGD 3710/4885 |
| US-10246457-B2 | Indazole and azaindazole Btk inhibitors | BTK, SYK, ABL1 | CYP3A4 1319/4885ACHE 2310/4885HPGD 3710/4885 |
| US-20160168122-A1 | NOVEL TRIAZINE DERIVATIVE | CBR3, HDAC3, SSTR3 | CYP3A4 642/4885ACHE 4058/4885HPGD 3932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.