Sugi Predict

Sugi Predict / Compounds / SCHEMBL1778173

SCHEMBL1778173

SCHEMBL1778173

CN(C)C1CCN(c2ccc(-n3ccc(COc4ccc(Cl)cn4)cc3=O)cn2)C1

nearest known ligand 0.49

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ MCHR1 Q99705 13/20 0.49
▸ DPP4 P27487 1/20 0.42
▸ TACR3 P29371 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25604509 0.91 MCHR1 (0.49) MCHR1DPP4
SCHEMBL1781464 0.85 MCHR1 (0.53) MCHR1DPP4
SCHEMBL1780431 0.83 MCHR1 (0.55) MCHR1DPP4
SCHEMBL1779387 0.83 MCHR1 (0.55) MCHR1DPP4
SCHEMBL1781603 0.83 MCHR1 (0.55) MCHR1DPP4
SCHEMBL1778177 0.82 CYP11B1 (0.35) MCHR1
SCHEMBL1782082 0.82 MCHR1 (0.49) MCHR1DPP4
SCHEMBL1781265 0.81 MCHR1 (0.48) MCHR1DPP4
SCHEMBL1779303 0.79 MCHR1 (0.77) MCHR1DPP4
SCHEMBL1781974 0.79 MCHR1 (0.49) MCHR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230373969-A1 MK2 INHIBITORS AND USES THEREOF XINTHERA, INC. 2023-11-23 — — US disclosed
US-20230265076-A1 MK2 INHIBITORS AND USES THEREOF XINTHERA, INC. 2023-08-24 — — US disclosed
US-11680056-B2 MK2 inhibitors and uses thereof XINTHERA, INC. (US) 2023-06-20 — — US disclosed
US-20220402892-A1 MK2 INHIBITORS AND USES THEREOF XINTHERA, INC. 2022-12-22 — — US disclosed
US-20110118261-A1 BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS GLAXO GROUP LIMITED 2011-05-19 — — US disclosed
US-20110118261-A1 BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS GLAXO GROUP LIMITED 2011-05-19 — — US disclosed
US-20110118261-A1 BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS GLAXO GROUP LIMITED 2011-05-19 — — US disclosed
WO-2009076387-A1 BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS GLAXO GROUP LIMITED (GB) 2009-06-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230373969-A1 MK2 INHIBITORS AND USES THEREOF MKNK2, ENPP2, MAPKAPK2 MCHR1 4509/4885DPP4 2449/4885TACR3 4100/4885
US-11680056-B2 MK2 inhibitors and uses thereof MKNK2, ENPP2, MAPKAPK2 MCHR1 4509/4885DPP4 2449/4885TACR3 4100/4885
US-20230265076-A1 MK2 INHIBITORS AND USES THEREOF MKNK2, ENPP2, MAPKAPK2 MCHR1 4509/4885DPP4 2449/4885TACR3 4100/4885
US-20220402892-A1 MK2 INHIBITORS AND USES THEREOF MKNK2, ENPP2, MAPKAPK2 MCHR1 4467/4885DPP4 2154/4885TACR3 3855/4885
US-20110118261-A1 BIS-PYRIDYLPYRIDONES AS MELANIN-CONCENTRATING HORMONE RECEPTOR 1 ANTAGONISTS MCHR1, MCHR2, MC1R MCHR1 1/4885DPP4 504/4885TACR3 364/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.