Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.58 |
| ▸ | MAPT | P10636 | 8/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | GLA | P06280 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12600477 | 0.85 | ALDH1A1 (0.46) | KDM4EMAPTALDH1A1HSD17B10PRKCZ | |
| SCHEMBL16296036 | 0.85 | KDM4E (0.56) | KDM4EMAPTALDH1A1HSD17B10ALOX15 | |
| SCHEMBL2285856 | 0.84 | MAPT (0.49) | KDM4EMAPTALDH1A1HSD17B10ALOX15 | |
| SCHEMBL16294694 | 0.76 | MAPT (0.66) | KDM4EMAPTALDH1A1HSD17B10MEN1 | |
| SCHEMBL17747474 | 0.76 | ALDH1A1 (0.56) | KDM4EMAPTALDH1A1HSD17B10MEN1 | |
| SCHEMBL935141 | 0.74 | ALDH1A1 (1.00) | KDM4EMAPTALDH1A1HSD17B10ALOX15 | |
| SCHEMBL3064294 | 0.74 | MAPT (0.67) | KDM4EMAPTALDH1A1HSD17B10ALOX15 | |
| SCHEMBL12377460 | 0.72 | MAPT (0.51) | KDM4EMAPTALDH1A1HSD17B10ALOX15 | |
| SCHEMBL13914287 | 0.71 | KDM4E (0.63) | KDM4EMAPTALDH1A1HSD17B10PRKCZ | |
| SCHEMBL12377457 | 0.70 | ALDH1A1 (0.43) | KDM4EMAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943637-B2 | Thienopyridine derivatives and the use thereof as HSP90 modulators | MERCK PATENT GMBH (DE) | 2011-05-17 | — | — | US | disclosed |
| US-20090054452-A1 | Thienopyridine Derivatives and the Use Thereof as Hsp90 Modulators | MERCK PATENT GMBH (DE) | 2009-02-26 | — | — | US | disclosed |
| EP-1853609-A1 | THIENOPYRIDINE DERIVATIVES AND USE THEREOF AS HSP90 MODULATORS | Merck Patent GmbH (DE) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006092202-A1 | THIENOPYRIDINE DERIVATIVES AND USE THEREOF AS HSP90 MODULATORS | MERCK PATENT GMBH (DE) | 2006-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054452-A1 | Thienopyridine Derivatives and the Use Thereof as Hsp90 Modulators | HSP90AA1, HSP90AB1, HSP90AB2P | KDM4E 3565/4885MAPT 1792/4885ALDH1A1 1033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.