Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 20/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17784845 | 0.96 | KLKB1 (0.78) | KLKB1 | |
| SCHEMBL17784852 | 0.86 | KLKB1 (0.67) | KLKB1 | |
| SCHEMBL21985437 | 0.86 | KLKB1 (0.67) | KLKB1 | |
| SCHEMBL29365582 | 0.85 | KLKB1 (0.70) | KLKB1 | |
| SCHEMBL17785269 | 0.84 | KLKB1 (1.00) | KLKB1 | |
| SCHEMBL22491826 | 0.81 | KLKB1 (0.65) | KLKB1 | |
| SCHEMBL17786840 | 0.80 | KLKB1 (0.66) | KLKB1 | |
| SCHEMBL29324563 | 0.80 | KLKB1 (0.59) | KLKB1 | |
| SCHEMBL17785268 | 0.80 | KLKB1 (0.69) | KLKB1 | |
| SCHEMBL21190114 | 0.80 | KLKB1 (0.57) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3982961-A1 | TREATMENTS OF ANGIOEDEMA | Kalvista Pharmaceuticals Limited (GB) | 2022-04-20 | — | — | EP | disclosed |
| WO-2020249979-A1 | TREATMENTS OF ANGIOEDEMA | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2020-12-17 | — | — | WO | disclosed |
| EP-3224256-A1 | N-((HET)ARYLMETHYL)-HETEROARYL-CARBOXAMIDES COMPOUNDS AS PLASMA KALLIKREIN INHIBITORS, | Kalvista Pharmaceuticals Limited (GB) | 2017-10-04 | — | — | EP | disclosed |
| WO-2016083820-A1 | N-((HET)ARYLMETHYL)-HETEROARYL-CARBOXAMIDES COMPOUNDS AS PLASMA KALLIKREIN INHIBITORS, | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-06-02 | — | — | WO | disclosed |