Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | P4HB | P07237 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.31 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17785725 | 0.90 | MAPT (0.40) | ALDH1A1MAPTP4HBAR | |
| SCHEMBL19657580 | 0.77 | MAPT (0.39) | ALDH1A1MAPTP4HBARGFER | |
| SCHEMBL23384713 | 0.76 | ALDH1A1 (0.53) | ALDH1A1MAPTDRD2DRD4P4HB | |
| SCHEMBL30727376 | 0.76 | ALDH1A1 (0.53) | ALDH1A1MAPTDRD2DRD4P4HB | |
| SCHEMBL6101285 | 0.72 | ALDH1A1 (0.49) | ALDH1A1MAPTDRD2DRD4P4HB | |
| SCHEMBL23063842 | 0.72 | ALDH1A1 (0.53) | ALDH1A1MAPTDRD2DRD4AR | |
| SCHEMBL23384782 | 0.72 | ALDH1A1 (0.53) | ALDH1A1MAPTDRD2DRD4AR | |
| SCHEMBL13946269 | 0.72 | ALDH1A1 (0.53) | ALDH1A1MAPTDRD2DRD4AR | |
| SCHEMBL17799539 | 0.71 | ALDH1A1 (0.42) | ALDH1A1MAPTAR | |
| SCHEMBL30993512 | 0.71 | ALDH1A1 (0.42) | ALDH1A1MAPTAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3224258-A1 | 4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | Genentech, Inc. (US) | 2017-10-04 | — | — | EP | disclosed |
| WO-2016086200-A9 | 4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | GENENTECH, INC. (US) | 2016-06-23 | — | — | WO | disclosed |
| WO-2016086200-A1 | 4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS | GENENTECH, INC. (US) | 2016-06-02 | — | — | WO | disclosed |