Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dihydroxyacetone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | OR51E2 | Q9H255 | 3/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.33 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dihydroxyacetone SCHEMBL70 | 0.91 | — | — | |
| Dihydroxyacetone SCHEMBL2555249 | 0.91 | OR51E2 (0.40) | OR51E2ACETDP1 | |
| Dihydroxyacetone SCHEMBL28114031 | 0.86 | — | — | |
| Dihydroxyacetone SCHEMBL290385 | 0.86 | — | — | |
| Dihydroxyacetone SCHEMBL29350199 | 0.86 | — | — | |
| Bicarbonate SCHEMBL1260607 | 0.85 | — | — | |
| Dihydroxyacetone SCHEMBL8046819 | 0.84 | FFAR3 (0.54) | CA1OR51E2ACELMNAEGLN1 | |
| Dihydroxyacetone SCHEMBL6572373 | 0.84 | FFAR3 (0.54) | CA1OR51E2ACELMNAEGLN1 | |
| Dihydroxyacetone SCHEMBL27878998 | 0.82 | — | — | |
| Dihydroxyacetone SCHEMBL28636804 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016086118-A1 | GLYCEROL-BASED POLYCARBONATES | TRUSTEES OF BOSTON UNIVERSITY (US) | 2016-06-02 | — | — | WO | disclosed |