Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL6572375 | 0.92 | FFAR3 (0.58) | FFAR3LCKFYNTP53CA1 | |
| SCHEMBL167720 | 0.91 | LMNA (0.46) | FFAR3LCKFYNTP53CA1 | |
| SCHEMBL19840129 | 0.91 | — | — | |
| SCHEMBL71 | 0.91 | — | — | |
| SCHEMBL290386 | 0.87 | — | — | |
| Charcoal, Activated SCHEMBL29904853 | 0.87 | — | — | |
| Phosphine SCHEMBL28100050 | 0.87 | — | — | |
| Water SCHEMBL9956155 | 0.87 | — | — | |
| Acetone SCHEMBL5542143 | 0.87 | LMNA (0.55) | FFAR3LCKFYNTP53CA1 | |
| Charcoal, Activated SCHEMBL31258460 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016086118-A1 | GLYCEROL-BASED POLYCARBONATES | TRUSTEES OF BOSTON UNIVERSITY (US) | 2016-06-02 | — | — | WO | disclosed |