Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.62 |
| ▸ | BACE1 | P56817 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 8/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 6/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.61 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 6/20 | 0.53 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.53 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17786431 | 0.93 | ACHE (0.55) | ACHEBACE1MAPTKDM4EMEN1 | |
| SCHEMBL12933894 | 0.89 | MAPT (0.78) | ACHEBACE1MAPTKDM4EMEN1 | |
| SCHEMBL17786512 | 0.86 | KDM4E (0.67) | ACHEMAPTKDM4EMEN1CYP3A4 | |
| SCHEMBL5130608 | 0.86 | MAPT (0.70) | ACHEMAPTKDM4EMEN1CYP3A4 | |
| SCHEMBL17786587 | 0.85 | MAPT (0.57) | ACHEBACE1MAPTKDM4EMEN1 | |
| SCHEMBL17786640 | 0.85 | CYP1A2 (0.60) | ACHEBACE1MAPTKDM4EMEN1 | |
| SCHEMBL7656936 | 0.83 | MAPT (0.68) | ACHEBACE1MAPTKDM4EMEN1 | |
| SCHEMBL17786466 | 0.83 | CSNK2A2 (0.75) | ACHEBACE1MAPTKDM4EMEN1 | |
| SCHEMBL25225095 | 0.81 | ACHE (0.71) | ACHEBACE1MAPTKDM4EMEN1 | |
| SCHEMBL17786589 | 0.81 | MAPT (0.56) | ACHEMAPTKDM4EMEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016083490-A1 | COMPOUNDS FOR THE TREATMENT OF AMYLOID-ASSOCIATED DISEASES | REMYND NV (BE) | 2016-06-02 | — | — | WO | disclosed |