Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 14/20 | 0.53 |
| ▸ | F11 | P03951 | 5/20 | 0.49 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.42 |
| ▸ | ME2 | P23368 | 1/20 | 0.40 |
| ▸ | ME1 | P48163 | 1/20 | 0.40 |
| ▸ | ME3 | Q16798 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17786970 | 0.92 | KLKB1 (0.59) | KLKB1F11CACNA1H | |
| SCHEMBL16246763 | 0.81 | KLKB1 (0.61) | KLKB1F11AOC3CACNA1H | |
| SCHEMBL18725232 | 0.80 | KLKB1 (0.47) | KLKB1F11AOC3CACNA1H | |
| SCHEMBL18725234 | 0.78 | KLKB1 (0.46) | KLKB1AOC3 | |
| SCHEMBL16246851 | 0.78 | KLKB1 (0.60) | KLKB1AOC3 | |
| SCHEMBL31339412 | 0.78 | KLKB1 (0.63) | KLKB1F11 | |
| SCHEMBL16246724 | 0.78 | KLKB1 (0.63) | KLKB1F11 | |
| SCHEMBL17786819 | 0.78 | KLKB1 (0.56) | KLKB1F11 | |
| SCHEMBL28339182 | 0.75 | KLKB1 (0.59) | KLKB1F11CACNA1H | |
| SCHEMBL17685591 | 0.74 | KLKB1 (0.45) | KLKB1F11AOC3CACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016083816-A1 | N-((HETEROARYLMETHYL)-HETEROARYL-CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-06-02 | — | — | WO | claimed |
| WO-2016083816-A1 | N-((HETEROARYLMETHYL)-HETEROARYL-CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-06-02 | — | — | WO | disclosed |