Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 11/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 7/20 | 0.41 |
| ▸ | F11 | P03951 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16246763 | 0.83 | KLKB1 (0.61) | KLKB1AOC3CACNA1HF11 | |
| SCHEMBL17786970 | 0.82 | KLKB1 (0.59) | KLKB1CACNA1HF11 | |
| SCHEMBL16246851 | 0.80 | KLKB1 (0.60) | KLKB1AOC3 | |
| SCHEMBL31339412 | 0.80 | KLKB1 (0.63) | KLKB1F11 | |
| SCHEMBL16246724 | 0.80 | KLKB1 (0.63) | KLKB1F11 | |
| SCHEMBL17786820 | 0.80 | KLKB1 (0.53) | KLKB1AOC3CACNA1HF11 | |
| SCHEMBL18725234 | 0.79 | KLKB1 (0.46) | KLKB1AOC3 | |
| SCHEMBL17785375 | 0.76 | KLKB1 (0.58) | KLKB1F11 | |
| SCHEMBL17685591 | 0.76 | KLKB1 (0.45) | KLKB1AOC3CACNA1HF11 | |
| SCHEMBL17685593 | 0.76 | KLKB1 (0.43) | KLKB1AOC3CACNA1HF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305778-B1 | INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LTD (GB) | 2022-01-19 | — | — | EP | disclosed |
| EP-3305778-A1 | INHIBITORS OF PLASMA KALLIKREIN | Kalvista Pharmaceuticals Limited (GB) | 2018-04-11 | — | — | EP | disclosed |
| EP-2999697-B1 | HETEROCYCLIC DERIVATES | KALVISTA PHARMACEUTICALS LTD (GB) | 2017-04-19 | — | — | EP | disclosed |