Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 18/20 | 0.48 |
| ▸ | KLK1 | P06870 | 6/20 | 0.38 |
| ▸ | F9 | P00740 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17787004 | 0.92 | KLKB1 (0.48) | KLKB1KLK1 | |
| SCHEMBL17787011 | 0.91 | KLKB1 (0.52) | KLKB1KLK1F9F10 | |
| SCHEMBL17787154 | 0.90 | KLKB1 (0.43) | KLKB1KLK1 | |
| SCHEMBL17787124 | 0.89 | KLKB1 (0.46) | KLKB1KLK1 | |
| SCHEMBL17787137 | 0.89 | KLKB1 (0.46) | KLKB1KLK1 | |
| SCHEMBL17786867 | 0.85 | KLKB1 (0.51) | KLKB1KLK1 | |
| SCHEMBL17786783 | 0.85 | KLKB1 (0.49) | KLKB1KLK1 | |
| SCHEMBL17787076 | 0.83 | KLKB1 (0.53) | KLKB1KLK1 | |
| SCHEMBL17787059 | 0.83 | KLKB1 (0.44) | KLKB1KLK1 | |
| SCHEMBL17787215 | 0.82 | KLKB1 (0.48) | KLKB1KLK1F9F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016083816-A1 | N-((HETEROARYLMETHYL)-HETEROARYL-CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-06-02 | — | — | WO | claimed |
| WO-2016083816-A1 | N-((HETEROARYLMETHYL)-HETEROARYL-CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-06-02 | — | — | WO | disclosed |