Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 17/20 | 0.48 |
| ▸ | KLK1 | P06870 | 8/20 | 0.43 |
| ▸ | F9 | P00740 | 2/20 | 0.40 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17787152 | 0.91 | KLKB1 (0.54) | KLKB1KLK1 | |
| SCHEMBL17786867 | 0.91 | KLKB1 (0.51) | KLKB1KLK1 | |
| SCHEMBL17787017 | 0.91 | KLKB1 (0.47) | KLKB1KLK1F9F10 | |
| SCHEMBL17787125 | 0.90 | KLKB1 (0.45) | KLKB1KLK1F9F10 | |
| SCHEMBL17787124 | 0.86 | KLKB1 (0.46) | KLKB1KLK1 | |
| SCHEMBL17787163 | 0.86 | KLKB1 (0.48) | KLKB1KLK1 | |
| SCHEMBL17787180 | 0.85 | KLKB1 (0.48) | KLKB1KLK1F9F10 | |
| SCHEMBL17787209 | 0.84 | KLKB1 (0.47) | KLKB1KLK1 | |
| SCHEMBL17787004 | 0.84 | KLKB1 (0.48) | KLKB1KLK1 | |
| SCHEMBL17786869 | 0.82 | KLKB1 (0.48) | KLKB1KLK1F9F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016083816-A1 | N-((HETEROARYLMETHYL)-HETEROARYL-CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-06-02 | — | — | WO | claimed |
| WO-2016083816-A1 | N-((HETEROARYLMETHYL)-HETEROARYL-CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-06-02 | — | — | WO | disclosed |