Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 18/20 | 0.57 |
| ▸ | F11 | P03951 | 5/20 | 0.56 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.46 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.46 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17786982 | 0.83 | KLKB1 (0.57) | KLKB1F11 | |
| SCHEMBL17786990 | 0.81 | KLKB1 (0.55) | KLKB1 | |
| SCHEMBL17786836 | 0.79 | KLKB1 (0.67) | KLKB1F11 | |
| SCHEMBL17786905 | 0.77 | KLKB1 (0.51) | KLKB1F11 | |
| SCHEMBL19668413 | 0.76 | KLKB1 (0.86) | KLKB1F11 | |
| SCHEMBL17785427 | 0.73 | KLKB1 (1.00) | KLKB1F11 | |
| SCHEMBL17786862 | 0.72 | KLKB1 (0.60) | KLKB1F11CACNA1GCACNA1HCACNA1I | |
| SCHEMBL21145591 | 0.72 | F11 (1.00) | KLKB1F11 | |
| SCHEMBL17786828 | 0.71 | KLKB1 (0.67) | KLKB1CACNA1GCACNA1HCACNA1I | |
| SCHEMBL17786984 | 0.71 | KLKB1 (0.72) | KLKB1F11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016083816-A1 | N-((HETEROARYLMETHYL)-HETEROARYL-CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-06-02 | — | — | WO | claimed |
| WO-2016083816-A1 | N-((HETEROARYLMETHYL)-HETEROARYL-CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-06-02 | — | — | WO | disclosed |