Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 20/20 | 0.56 |
| ▸ | F11 | P03951 | 1/20 | 0.44 |
| ▸ | KLK1 | P06870 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17786815 | 0.91 | KLKB1 (0.58) | KLKB1 | |
| SCHEMBL17786999 | 0.89 | KLKB1 (0.57) | KLKB1F11KLK1 | |
| SCHEMBL17787153 | 0.82 | KLKB1 (0.78) | KLKB1 | |
| SCHEMBL17786824 | 0.79 | KLKB1 (0.54) | KLKB1F11 | |
| SCHEMBL17786862 | 0.77 | KLKB1 (0.60) | KLKB1F11KLK1 | |
| SCHEMBL17786972 | 0.71 | KLKB1 (0.62) | KLKB1F11KLK1 | |
| SCHEMBL21177369 | 0.71 | KLKB1 (0.76) | KLKB1 | |
| SCHEMBL21178101 | 0.70 | KLKB1 (0.77) | KLKB1 | |
| SCHEMBL19780381 | 0.69 | KLKB1 (1.00) | KLKB1 | |
| SCHEMBL17786954 | 0.69 | KLKB1 (0.75) | KLKB1F11KLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016083816-A1 | N-((HETEROARYLMETHYL)-HETEROARYL-CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-06-02 | — | — | WO | claimed |
| WO-2016083816-A1 | N-((HETEROARYLMETHYL)-HETEROARYL-CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-06-02 | — | — | WO | disclosed |