Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 13/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25659787 | 0.77 | KLKB1 (0.47) | KLKB1 | |
| SCHEMBL17786809 | 0.74 | KLKB1 (0.46) | HTTKLKB1 | |
| SCHEMBL31172591 | 0.73 | HTT (0.44) | HTTKLKB1HDAC1HDAC6MEN1 | |
| SCHEMBL16246815 | 0.73 | KLKB1 (0.58) | KLKB1 | |
| SCHEMBL31172570 | 0.73 | HTT (0.41) | HTTKLKB1HDAC1HDAC6MEN1 | |
| SCHEMBL24863510 | 0.72 | KLKB1 (0.38) | KLKB1CACNA1H | |
| SCHEMBL31691366 | 0.72 | HTT (0.60) | HTTKLKB1HDAC1HDAC6MEN1 | |
| SCHEMBL17221362 | 0.71 | KLKB1 (0.47) | HTTKLKB1HDAC1HDAC6MEN1 | |
| SCHEMBL17786931 | 0.71 | HTT (0.49) | HTTKLKB1HDAC1HDAC6MEN1 | |
| SCHEMBL25660016 | 0.71 | KLKB1 (0.41) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016083816-A1 | N-((HETEROARYLMETHYL)-HETEROARYL-CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-06-02 | — | — | WO | claimed |
| WO-2016083816-A1 | N-((HETEROARYLMETHYL)-HETEROARYL-CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-06-02 | — | — | WO | disclosed |