Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6843345 | 0.86 | GAA (0.59) | GAAHTTPOLBPIK3CAPIK3CD | |
| SCHEMBL13551125 | 0.82 | PDE10A (0.44) | GAAMAPTTSHRMAPK1HSD17B10 | |
| SCHEMBL13551052 | 0.82 | HTR3E (0.43) | GAAMAPTTSHRMAPK1HSD17B10 | |
| SCHEMBL5329 | 0.81 | GRIN2D (0.53) | GAAHTTPOLBPIK3CAPIK3CD | |
| SCHEMBL29789768 | 0.81 | GRIN2D (0.53) | GAAHTTPOLBPIK3CAPIK3CD | |
| SCHEMBL22334883 | 0.79 | GAA (0.53) | GAAHTTPOLBPIK3CAPIK3CD | |
| SCHEMBL23770804 | 0.78 | HTR3E (0.64) | HTTTSHRMAPK1HSD17B10KDM4E | |
| SCHEMBL4945956 | 0.78 | GAA (0.59) | GAAHTTPOLBPIK3CAPIK3CD | |
| SCHEMBL12654053 | 0.78 | HTR3E (0.64) | GAAHTTPOLBPIK3CAPIK3CD | |
| SCHEMBL2371248 | 0.78 | GAA (0.51) | GAAHTTPOLBPIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315763-B1 | BENZIMIDAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-06-01 | — | — | EP | disclosed |