Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 19/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 19/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9864290 | 0.81 | HSD11B1 (0.47) | SLC6A4SLC6A3 | |
| SCHEMBL9864293 | 0.81 | HSD11B1 (0.47) | SLC6A4SLC6A3 | |
| SCHEMBL1350 | 0.80 | SLC6A4 (0.49) | SLC6A4SLC6A3SLC6A2CYP2C19CYP3A4 | |
| SCHEMBL7371362 | 0.77 | CHRM2 (0.49) | SLC6A4SLC6A3SLC6A2CYP2D6KCNH2 | |
| SCHEMBL3520530 | 0.77 | SLC6A4 (0.51) | SLC6A4SLC6A3SLC6A2CYP2D6KCNH2 | |
| SCHEMBL3519021 | 0.75 | CHRM2 (0.51) | SLC6A4SLC6A3SLC6A2CYP2D6KCNH2 | |
| SCHEMBL2795429 | 0.75 | AKR1C3 (0.58) | SLC6A4SLC6A3SLC6A2CYP2C19CYP3A4 | |
| SCHEMBL3521201 | 0.74 | SLC6A4 (0.40) | SLC6A4SLC6A3SLC6A2CYP2D6KCNH2 | |
| SCHEMBL3521200 | 0.74 | SLC6A4 (0.40) | SLC6A4SLC6A3SLC6A2CYP2D6KCNH2 | |
| SCHEMBL13253955 | 0.74 | SLC6A4 (0.40) | SLC6A4SLC6A3SLC6A2CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4814352-A | ANTIDEPRESSANT CYCLOBUTYL BENZYLAMINE | THE BOOTS COMPANY PLC (GB) | 1989-03-21 | — | — | US | disclosed |
| US-4806570-A | ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1989-02-21 | — | — | US | disclosed |
| US-4767790-A | ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1988-08-30 | — | — | US | disclosed |
| US-4746680-A | ANTIDEPRESSANTS | THE BOOTS COMPANY P.L.C. (GB) | 1988-05-24 | — | — | US | disclosed |
| US-4522828-A | CYCLOBUTYLALKYLAMINE COMPOUNDS, ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1985-06-11 | — | — | US | disclosed |