Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.54 |
| ▸ | BCR | P11274 | 2/20 | 0.54 |
| ▸ | INSR | P06213 | 6/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.42 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 3/20 | 0.41 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1779993 | 0.91 | AURKA (0.45) | AURKAABL1BCRINSRALK | |
| SCHEMBL15362142 | 0.90 | AURKA (0.47) | AURKAABL1BCRINSRALK | |
| SCHEMBL3866841 | 0.88 | ALK (0.44) | AURKAINSRALKSIRT6IGF1R | |
| SCHEMBL1781996 | 0.88 | AURKA (0.54) | AURKAABL1BCRINSRALK | |
| SCHEMBL1779562 | 0.88 | AURKA (0.57) | AURKAABL1BCRINSRALK | |
| SCHEMBL1781440 | 0.87 | AURKA (0.55) | AURKAABL1BCRINSRALK | |
| SCHEMBL1778032 | 0.86 | AURKA (0.42) | AURKAABL1BCRKIT | |
| SCHEMBL1777677 | 0.85 | AURKA (0.52) | AURKAABL1BCRINSRALK | |
| SCHEMBL1778917 | 0.85 | AURKA (0.48) | AURKAABL1BCRINSRALK | |
| SCHEMBL1779351 | 0.85 | AURKA (0.69) | AURKAABL1BCRKITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | claimed |
| EP-1904503-A1 | 1H-THIENO[2,3-C]-PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-04-02 | — | — | EP | claimed |
| WO-2007009898-A1 | 1H-THIENO[2,3-C]PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-01-25 | — | — | WO | claimed |
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | disclosed |