Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.54 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | BCR | P11274 | 2/20 | 0.52 |
| ▸ | INSR | P06213 | 4/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.43 |
| ▸ | IGF1R | P08069 | 2/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | LYN | P07948 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 4/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1779553 | 0.91 | AURKA (0.44) | AURKAABL1BCRINSRALK | |
| SCHEMBL15362115 | 0.90 | AURKA (0.46) | AURKAABL1BCRINSRALK | |
| SCHEMBL3868337 | 0.89 | CSF1R (0.45) | AURKAABL1INSRALKIGF1R | |
| SCHEMBL1779217 | 0.88 | AURKA (0.55) | AURKAABL1BCRINSRALK | |
| SCHEMBL1781440 | 0.87 | AURKA (0.55) | AURKAABL1BCRINSRALK | |
| SCHEMBL1779319 | 0.86 | AURKA (0.41) | AURKAABL1BCRCSF1RFLT3 | |
| SCHEMBL1779562 | 0.86 | AURKA (0.57) | AURKAABL1BCRINSRALK | |
| SCHEMBL1777770 | 0.85 | AURKA (0.55) | AURKAABL1BCRINSRALK | |
| SCHEMBL1777677 | 0.84 | AURKA (0.52) | AURKAABL1BCRINSRALK | |
| SCHEMBL1780828 | 0.84 | AURKA (0.45) | AURKAABL1BCRINSRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | claimed |
| EP-1904503-A1 | 1H-THIENO[2,3-C]-PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-04-02 | — | — | EP | claimed |
| WO-2007009898-A1 | 1H-THIENO[2,3-C]PYRAZOLE COMPOUNDS USEFUL AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-01-25 | — | — | WO | claimed |