Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.68 |
| ▸ | BCR | P11274 | 2/20 | 0.68 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 2/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 5/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.39 |
| ▸ | PPARA | Q07869 | 3/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1779493 | 0.99 | ABL1 (0.69) | ABL1BCRAURKACYP2C9MAPT | |
| SCHEMBL742638 | 0.95 | ABL1 (0.74) | ABL1BCRAURKACYP2C9MAPT | |
| SCHEMBL741183 | 0.94 | ABL1 (0.76) | ABL1BCRAURKACYP2C9MAPT | |
| SCHEMBL740752 | 0.94 | ABL1 (0.76) | ABL1BCRAURKACYP2C9MAPT | |
| SCHEMBL1779566 | 0.94 | ABL1 (0.59) | ABL1BCRAURKAMAPTTSHR | |
| SCHEMBL740623 | 0.93 | ABL1 (0.72) | ABL1BCRAURKACYP2C9MAPT | |
| SCHEMBL739604 | 0.89 | ABL1 (0.66) | ABL1BCRAURKAACKR3HDAC1 | |
| SCHEMBL743125 | 0.89 | ABL1 (0.65) | ABL1BCRAURKACYP2C9MAPT | |
| SCHEMBL740990 | 0.89 | ABL1 (0.65) | ABL1BCRAURKACYP2C9MAPT | |
| SCHEMBL3866746 | 0.88 | ABL1 (0.50) | ABL1BCRAURKACYP2C9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | disclosed |