Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.59 |
| ▸ | BCR | P11274 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL742258 | 0.95 | ABL1 (0.65) | ABL1BCRMAPTTSHRAURKA | |
| SCHEMBL1779462 | 0.94 | ABL1 (0.68) | ABL1BCRMAPTTSHRAURKA | |
| SCHEMBL1779493 | 0.93 | ABL1 (0.69) | ABL1BCRMAPTTSHRAURKA | |
| SCHEMBL3874968 | 0.89 | MAPT (0.54) | MAPTTSHRAURKARAB9AHIF1A | |
| SCHEMBL739685 | 0.88 | ABL1 (0.56) | ABL1BCRMAPTAURKARAB9A | |
| SCHEMBL742638 | 0.88 | ABL1 (0.74) | ABL1BCRMAPTAURKARAB9A | |
| SCHEMBL740623 | 0.88 | ABL1 (0.72) | ABL1BCRMAPTAURKARAB9A | |
| SCHEMBL740752 | 0.87 | ABL1 (0.76) | ABL1BCRMAPTAURKARAB9A | |
| SCHEMBL739604 | 0.87 | ABL1 (0.66) | ABL1BCRAURKAHDAC1FLT3 | |
| SCHEMBL741183 | 0.87 | ABL1 (0.76) | ABL1BCRMAPTAURKARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943654-B2 | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-05-17 | — | — | US | disclosed |