Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 5/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lithium Ion SCHEMBL11741290 | 0.94 | CA2 (0.32) | CA2CA1CYP3A4TSHRNFKB1 | |
| SCHEMBL15022945 | 0.94 | CA1 (0.36) | CA2CA1CYP3A4TSHRNFKB1 | |
| SCHEMBL19506735 | 0.71 | DPP4 (0.33) | TSHRDPP4 | |
| SCHEMBL10473952 | 0.71 | DPP4 (0.33) | TSHRDPP4 | |
| Tert-Butylamine SCHEMBL19171304 | 0.71 | CA2 (0.32) | CA2CA1CYP3A4TSHRNFKB1 | |
| Silver SCHEMBL978713 | 0.70 | CA1 (0.43) | CA2CA1CYP3A4TSHRNFKB1 | |
| SCHEMBL3532262 | 0.70 | CA1 (0.43) | CA2CA1CYP3A4TSHRNFKB1 | |
| Silver SCHEMBL25782 | 0.70 | — | — | |
| SCHEMBL125061 | 0.69 | — | — | |
| Silver SCHEMBL17797180 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2610248-B1 | METHOD FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE BY MEANS OF COUPLING METHOD USING A PALLADIUM COMPOUND | TEIJIN PHARMA LTD (JP) | 2016-06-08 | — | — | EP | claimed |