Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 10/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TPH1 | P17752 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17797399 | 0.93 | S1PR1 (0.45) | S1PR1S1PR3MAPTKDM4EHSD17B10 | |
| SCHEMBL15662510 | 0.93 | MAPT (0.45) | S1PR1S1PR3SMN1; SMN2MAPTTPH1 | |
| SCHEMBL177105 | 0.92 | S1PR1 (0.55) | S1PR1S1PR3 | |
| SCHEMBL15662798 | 0.92 | SMN1; SMN2 (0.49) | S1PR1S1PR3SMN1; SMN2MAPTTPH1 | |
| SCHEMBL17797432 | 0.91 | S1PR1 (0.52) | S1PR1S1PR3SMN1; SMN2MAPTKDM4E | |
| SCHEMBL178195 | 0.91 | S1PR1 (0.46) | S1PR1S1PR3SMN1; SMN2MAPTTPH1 | |
| SCHEMBL17797433 | 0.90 | S1PR1 (0.44) | S1PR1S1PR3 | |
| SCHEMBL17797420 | 0.90 | S1PR1 (0.42) | S1PR1S1PR3MAPTTP53 | |
| SCHEMBL15662730 | 0.89 | TPH1 (0.40) | S1PR1S1PR3SMN1; SMN2MAPTTPH1 | |
| SCHEMBL15662834 | 0.85 | SMN1; SMN2 (0.52) | S1PR1S1PR3SMN1; SMN2MAPTTPH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344484-B1 | S1P RECEPTORS MODULATORS AND USE THEREOF | AKAAL PHARMA PTY LTD (AU) | 2016-06-08 | — | — | EP | disclosed |