Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17797626 | 0.94 | BRD4 (0.49) | NR1H2BRD4ATAD2RIPK1PDK1 | |
| SCHEMBL396130 | 0.90 | NR1H2 (0.63) | NR1H2BRD4ATAD2HSD17B3HDAC8 | |
| SCHEMBL11327160 | 0.86 | NR1H2 (0.56) | NR1H2BRD4ATAD2RIPK1PDK1 | |
| SCHEMBL381428 | 0.84 | NR1H2 (0.56) | NR1H2BRD4ATAD2HDAC6HSD17B3 | |
| SCHEMBL31481211 | 0.84 | NR1H2 (0.50) | NR1H2BRD4ATAD2RIPK1PDK1 | |
| SCHEMBL1393814 | 0.83 | NR1H2 (0.50) | NR1H2BRD4ATAD2PDK2ALDH1A1 | |
| SCHEMBL5429574 | 0.83 | ESR2 (0.56) | RIPK1ALDH1A1TMEM97SIGMAR1ESR1 | |
| SCHEMBL3353692 | 0.82 | ESR1 (0.60) | NR1H2BRD4ATAD2RIPK1PDK1 | |
| SCHEMBL29040812 | 0.81 | ABHD6 (0.50) | RIPK1PDK1PDK2PDK3PDK4 | |
| SCHEMBL17797658 | 0.80 | NR1H2 (0.55) | NR1H2BRD4ATAD2ALDH1A1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160159774-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE CAR LLC (BM) | 2016-06-09 | — | — | US | disclosed |
| WO-2016090079-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE AVILOMICS RESEARCH, INC. (US) | 2016-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160159774-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | ABCG2, CYP3A43, CYP3A5 | NR1H2 557/4885BRD4 1396/4885ATAD2 4379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.