Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 14/20 | 0.51 |
| ▸ | NPC1 | O15118 | 13/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.49 |
| ▸ | RELA | Q04206 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | STAT1 | P42224 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3652815 | 0.87 | NPC1 (0.49) | RAB9ANPC1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL11896022 | 0.81 | NPC1 (0.70) | RAB9ANPC1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL30494024 | 0.81 | NPC1 (0.65) | RAB9ANPC1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL29119510 | 0.79 | BAZ2B (0.54) | RAB9ANPC1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL17797663 | 0.79 | TMEM97 (0.55) | RAB9ANPC1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL2248318 | 0.79 | ACLY (0.53) | RAB9ANPC1ALDH1A1KDM4E | |
| SCHEMBL17797675 | 0.78 | NOTUM (0.56) | RAB9ANPC1SMN1; SMN2ALDH1A1TP53 | |
| SCHEMBL17797709 | 0.78 | KMT2A (0.46) | RAB9ANPC1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL8130701 | 0.77 | NPC1 (0.65) | RAB9ANPC1POLBSMN1; SMN2NFKB1 | |
| SCHEMBL17797681 | 0.77 | KDM4E (0.44) | RAB9ANPC1POLBSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160159774-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE CAR LLC (BM) | 2016-06-09 | — | — | US | disclosed |
| WO-2016090079-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE AVILOMICS RESEARCH, INC. (US) | 2016-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160159774-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | ABCG2, CYP3A43, CYP3A5 | RAB9A 580/4885NPC1 48/4885POLB 3726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.