Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 14/20 | 0.72 |
| ▸ | GSK3A | P49840 | 12/20 | 0.72 |
| ▸ | CDK7 | P50613 | 5/20 | 0.72 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.72 |
| ▸ | IGF1R | P08069 | 5/20 | 0.72 |
| ▸ | LCK | P06239 | 4/20 | 0.72 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.72 |
| ▸ | JAK2 | O60674 | 4/20 | 0.72 |
| ▸ | BTK | Q06187 | 1/20 | 0.72 |
| ▸ | CDK5 | Q00535 | 11/20 | 0.52 |
| ▸ | AURKA | O14965 | 4/20 | 0.52 |
| ▸ | ABL1 | P00519 | 4/20 | 0.52 |
| ▸ | RET | P07949 | 4/20 | 0.52 |
| ▸ | FLT3 | P36888 | 4/20 | 0.52 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.52 |
| ▸ | PAK4 | O96013 | 3/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.52 |
| ▸ | FYN | P06241 | 3/20 | 0.52 |
| ▸ | CSF1R | P07333 | 3/20 | 0.52 |
| ▸ | MET | P08581 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7171199 | 0.89 | GSK3B (0.76) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL1778596 | 0.84 | GSK3B (1.00) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL1779101 | 0.83 | GSK3B (0.89) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL3091781 | 0.80 | IGF1R (0.44) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL2760530 | 0.78 | GSK3B (0.66) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL1777186 | 0.78 | GSK3B (0.65) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL1778813 | 0.77 | GSK3B (0.71) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL27634819 | 0.77 | GSK3B (0.71) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL1777173 | 0.77 | CCNB2 (0.60) | GSK3BGSK3ACDK7AURKBIGF1R | |
| SCHEMBL3104144 | 0.76 | GSK3B (0.69) | GSK3BGSK3ACDK7AURKBIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |
| EP-2233486-A1 | Azaindoles | Aventis Pharma Limited (GB) | 2010-09-29 | — | — | EP | disclosed |
| US-20050267304-A1 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2005-12-01 | — | — | US | disclosed |
| US-6897207-B2 | Azaindoles | AVENTIS PHARMACEUTICALS INC. (US) | 2005-05-24 | — | — | US | disclosed |
| US-20040053931-A1 | Azaindoles | AVENTIS PHARMACEUTICALS INC. | 2004-03-18 | — | — | US | disclosed |
| EP-1397360-A1 | AZAINDOLES | Aventis Pharma Limited (GB) | 2004-03-17 | — | — | EP | disclosed |
| WO-2003000688-A1 | AZAINDOLES | AVENTIS PHARMA LIMITED (GB) | 2003-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040053931-A1 | Azaindoles | CDKN1A, CDK7, CDK2 | GSK3B 409/4885GSK3A 456/4885CDK7 2/4885 |
| US-20050267304-A1 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | MAP3K20, MAP3K12, MAP3K19 | GSK3B 187/4885GSK3A 176/4885CDK7 166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.