Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 8/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.38 |
| ▸ | TEC | P42680 | 6/20 | 0.37 |
| ▸ | TXK | P42681 | 6/20 | 0.37 |
| ▸ | BMX | P51813 | 6/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | ITK | Q08881 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | IGF1R | P08069 | 2/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17800128 | 1.00 | BTK (0.38) | BTKTNK2TECTXKBMX | |
| SCHEMBL18849915 | 0.85 | ATM (0.47) | BTKTNK2 | |
| SCHEMBL20550584 | 0.85 | ATM (0.47) | BTKTNK2 | |
| SCHEMBL28623986 | 0.78 | BTK (0.42) | BTKTNK2TECTXKBMX | |
| SCHEMBL20550691 | 0.72 | BTK (0.41) | BTKTNK2TECTXKBMX | |
| SCHEMBL30468175 | 0.69 | TNK2 (0.48) | BTKTNK2IGF1R | |
| SCHEMBL18849709 | 0.69 | TNK2 (0.41) | BTKTNK2TECTXKBMX | |
| SCHEMBL14636998 | 0.68 | BTK (0.41) | BTKTNK2TECTXKBMX | |
| SCHEMBL18099733 | 0.67 | ABL1 (0.53) | BTKTNK2ABL1SRCRET | |
| SCHEMBL18849914 | 0.66 | ABL1 (0.43) | BTKTNK2ABL1SRCRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160159810-A1 | 4-IMIDAZOPYRIDAZIN-1-YL-BENZAMIDES AND 4-IMIDAZOTRIAZIN-1-YL-BENZAMIDES AS BTK INHIBITORS | MERCK SHARP & DOHME B.V. (NL) | 2016-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160159810-A1 | 4-IMIDAZOPYRIDAZIN-1-YL-BENZAMIDES AND 4-IMIDAZOTRIAZIN-1-YL-BENZAMIDES AS BTK INHIBITORS | BTK, ABL1, SYK | BTK 1/4885TNK2 287/4885TEC 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.