Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.52 |
| ▸ | CDK7 | P50613 | 4/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.42 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.40 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.40 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4084573 | 0.80 | JAK2 (0.45) | LRRK2CDK7CHEK1JAK2 | |
| SCHEMBL13812167 | 0.75 | FGFR1 (0.48) | LRRK2CDK7CHEK1JAK2CSNK1D | |
| SCHEMBL5382081 | 0.74 | LRRK2 (0.59) | LRRK2CDK7CHEK1CAMKK2MARK2 | |
| SCHEMBL4085294 | 0.73 | CLK2 (0.41) | LRRK2CDK7CHEK1JAK2CSNK1D | |
| SCHEMBL17801058 | 0.73 | CSNK1D (0.76) | LRRK2CDK7CHEK1CSNK1D | |
| SCHEMBL13876985 | 0.72 | CSNK1D (0.47) | CDK7CHEK1JAK2CSNK1DDYRK3 | |
| SCHEMBL4169696 | 0.72 | CSNK1D (0.47) | CDK7CHEK1JAK2CSNK1DDYRK3 | |
| SCHEMBL4084821 | 0.72 | CSNK1D (0.57) | JAK2CSNK1DDYRK3GSK3BPIM3 | |
| SCHEMBL4085679 | 0.71 | LRRK2 (0.42) | LRRK2JAK2CSNK1DDYRK3GSK3B | |
| SCHEMBL17801044 | 0.70 | LRRK2 (0.52) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |