Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 16/20 | 0.52 |
| ▸ | ITK | Q08881 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5389028 | 0.82 | CSNK1D (0.46) | ITKMKNK1 | |
| SCHEMBL17801023 | 0.79 | LRRK2 (0.52) | LRRK2ITKTRPA1SCN5ASCN9A | |
| SCHEMBL17801060 | 0.78 | PDPK1 (0.60) | LRRK2ITK | |
| SCHEMBL1664137 | 0.76 | LRRK2 (0.58) | LRRK2ITKTRPA1SCN5ASCN9A | |
| SCHEMBL17801064 | 0.76 | DCLK1 (0.65) | LRRK2ITKTRPA1SCN5ASCN9A | |
| SCHEMBL17801062 | 0.75 | BTK (0.50) | MKNK1 | |
| SCHEMBL2857828 | 0.73 | LRRK2 (0.54) | LRRK2ITKTRPA1SCN5ASCN9A | |
| SCHEMBL5379650 | 0.73 | MAPK1 (0.61) | LRRK2ITKTRPA1SCN5ASCN9A | |
| SCHEMBL2859279 | 0.73 | ITK (0.64) | LRRK2ITKMKNK1 | |
| SCHEMBL12317928 | 0.72 | IDO1 (0.65) | LRRK2ITKTRPA1SCN5ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |