Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 8/20 | 0.54 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | PAK4 | O96013 | 1/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19466043 | 0.84 | HPSE (0.73) | HPSEKDM4ENPC1RAB9AMEN1 | |
| SCHEMBL3533024 | 0.81 | PDPK1 (0.73) | FLT3PDPK1PAK4CDK2CHEK1 | |
| SCHEMBL4912822 | 0.81 | FGFR1 (0.59) | FLT3PDPK1PAK4CDK2CHEK1 | |
| SCHEMBL5379078 | 0.79 | KDM4E (0.65) | PDPK1KDM4ENPC1RAB9AMEN1 | |
| SCHEMBL17801060 | 0.77 | PDPK1 (0.60) | PDPK1KDM4ECDK2ALDH1A1CHEK1 | |
| SCHEMBL1224535 | 0.76 | FLT3 (0.66) | FLT3PDPK1KDM4ENPC1RAB9A | |
| SCHEMBL1225786 | 0.75 | CHEK1 (0.82) | FLT3PDPK1PAK4CDK2CHEK1 | |
| SCHEMBL1225453 | 0.75 | PAK4 (0.63) | FLT3PDPK1PAK4CDK2CHEK1 | |
| SCHEMBL15862535 | 0.75 | CLK2 (0.73) | PDPK1MMP2MMP9MMP8MMP13 | |
| SCHEMBL5508118 | 0.74 | PDPK1 (0.74) | FLT3PDPK1KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |