Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 5/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
| ▸ | FLT1 | P17948 | 1/20 | 0.54 |
| ▸ | ITK | Q08881 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | ATR | Q13535 | 1/20 | 0.52 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | CCND3 | P30281 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.47 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.47 |
| ▸ | RHEB | Q15382 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801048 | 0.90 | PDPK1 (0.62) | PDPK1FGFR1FLT1ITKCHEK1 | |
| SCHEMBL1225637 | 0.86 | PDPK1 (0.67) | PDPK1FGFR1FLT1ITKCHEK1 | |
| SCHEMBL3533024 | 0.86 | PDPK1 (0.73) | PDPK1FGFR1FLT1ITKCHEK1 | |
| SCHEMBL25418501 | 0.85 | PDPK1 (0.71) | PDPK1FGFR1FLT1ITKCHEK1 | |
| SCHEMBL31472525 | 0.85 | PDPK1 (0.71) | PDPK1FGFR1FLT1ITKCHEK1 | |
| SCHEMBL5379078 | 0.84 | KDM4E (0.65) | PDPK1FGFR1FLT1ITKCHEK1 | |
| SCHEMBL3337258 | 0.82 | NPC1 (0.66) | ATRCHEK2PKN1PKN2RHEB | |
| SCHEMBL484587 | 0.80 | NPC1 (0.64) | ATRCHEK2PKN1PKN2RHEB | |
| SCHEMBL3533531 | 0.79 | FGFR1 (0.66) | PDPK1FGFR1FLT1ITKCHEK1 | |
| SCHEMBL5951956 | 0.79 | FGFR1 (0.66) | PDPK1FGFR1FLT1ITKCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |