Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCLK1 | O15075 | 1/20 | 0.65 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.65 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.65 |
| ▸ | CSF1R | P07333 | 1/20 | 0.65 |
| ▸ | FER | P16591 | 1/20 | 0.65 |
| ▸ | CDK2 | P24941 | 1/20 | 0.65 |
| ▸ | MARK3 | P27448 | 1/20 | 0.65 |
| ▸ | FLT4 | P35916 | 1/20 | 0.65 |
| ▸ | FLT3 | P36888 | 1/20 | 0.65 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.65 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.65 |
| ▸ | CLK2 | P49760 | 1/20 | 0.65 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.65 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.65 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.65 |
| ▸ | STK3 | Q13188 | 1/20 | 0.65 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.65 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.65 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1664137 | 0.82 | LRRK2 (0.58) | LRRK2AXLTRPA1SCN5ASCN9A | |
| SCHEMBL4734012 | 0.80 | CSNK1D (0.71) | DCLK1PRKD3MAP4K4CHEK2CSF1R | |
| SCHEMBL4316858 | 0.79 | DCLK1 (1.00) | DCLK1PRKD3MAP4K4CHEK2CSF1R | |
| SCHEMBL2731639 | 0.79 | FLT3 (0.75) | DCLK1PRKD3MAP4K4CHEK2CSF1R | |
| SCHEMBL2857828 | 0.79 | LRRK2 (0.54) | CSNK1DLRRK2TRPA1SCN5ASCN9A | |
| SCHEMBL5379650 | 0.79 | MAPK1 (0.61) | LRRK2PDPK1TRPA1SCN5ASCN9A | |
| SCHEMBL2859279 | 0.78 | ITK (0.64) | DCLK1PRKD3MAP4K4CHEK2CSF1R | |
| SCHEMBL12317928 | 0.78 | IDO1 (0.65) | LRRK2PDPK1TRPA1SCN5ASCN9A | |
| SCHEMBL29130516 | 0.77 | TDO2 (0.69) | HTR2B | |
| SCHEMBL2242478 | 0.77 | LRRK2 (0.59) | LRRK2TRPA1SCN5ASCN9AMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |