Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 17/20 | 0.48 |
| ▸ | F11 | P03951 | 12/20 | 0.48 |
| ▸ | TPSB2 | P20231 | 9/20 | 0.48 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | F7 | P08709 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17802661 | 0.91 | CFD (0.58) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL16396680 | 0.87 | CFD (0.58) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL16410362 | 0.87 | CFD (0.42) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL16396682 | 0.87 | CFD (0.58) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL16397135 | 0.84 | CFD (0.42) | CFDF11TPSB2 | |
| SCHEMBL16396699 | 0.84 | GAA (0.39) | CFDF11TPSB2 | |
| SCHEMBL16410404 | 0.84 | CFD (0.69) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL17802711 | 0.82 | CFD (0.52) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL17764455 | 0.78 | CFD (0.67) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL16402248 | 0.78 | CFD (0.67) | CFDF11TPSB2KLKB1PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016088082-A1 | AMIDOMETHYL-BIARYL DERIVATIVES COMPLEMENT FACTOR D INHIBITORS AND USES THEREOF | NOVARTIS AG (CH) | 2016-06-09 | — | — | WO | disclosed |