Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CFD | P00746 | 6/20 | 0.43 |
| ▸ | F11 | P03951 | 6/20 | 0.43 |
| ▸ | TPSB2 | P20231 | 4/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | F7 | P08709 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17802741 | 1.00 | HPGD (0.46) | HPGDALDH1A1CFDF11TPSB2 | |
| SCHEMBL17802752 | 0.92 | CFD (0.52) | HPGDCFDF11TPSB2KLKB1 | |
| SCHEMBL17802738 | 0.92 | CFD (0.52) | HPGDCFDF11TPSB2KLKB1 | |
| SCHEMBL16397447 | 0.85 | CFD (0.61) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL17764488 | 0.85 | CFD (0.61) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL17802689 | 0.80 | CFD (0.57) | HPGDALDH1A1CFDF11TPSB2 | |
| SCHEMBL17802687 | 0.80 | CFD (0.57) | HPGDALDH1A1CFDF11TPSB2 | |
| SCHEMBL17802623 | 0.79 | CFD (0.58) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL17802711 | 0.77 | CFD (0.52) | CFDF11TPSB2KLKB1PLG | |
| SCHEMBL16396576 | 0.76 | CFD (0.56) | HPGDCFDF11TPSB2KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016088082-A1 | AMIDOMETHYL-BIARYL DERIVATIVES COMPLEMENT FACTOR D INHIBITORS AND USES THEREOF | NOVARTIS AG (CH) | 2016-06-09 | — | — | WO | disclosed |