Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | SLC16A3 | O15427 | 5/20 | 0.33 |
| ▸ | SLC16A1 | P53985 | 4/20 | 0.33 |
| ▸ | MCTS1 | Q9ULC4 | 4/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2927140 | 0.86 | PPARG (0.34) | SMN1; SMN2KDM4E | |
| SCHEMBL31124766 | 0.81 | TSHR (0.35) | SLC16A3TTRSMN1; SMN2 | |
| SCHEMBL16818604 | 0.81 | TACR1 (0.34) | SLC16A3SLC16A1MCTS1MEN1KMT2A | |
| SCHEMBL9347235 | 0.80 | ESR1 (0.43) | TP53GAAMAPTMEN1KMT2A | |
| SCHEMBL23070394 | 0.80 | ALOX5AP (0.31) | SLC16A3SLC16A1MCTS1 | |
| SCHEMBL17803751 | 0.80 | NPC1 (0.32) | MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1314001 | 0.80 | AGXT (0.42) | MAPTMAOBSMN1; SMN2 | |
| SCHEMBL8149467 | 0.79 | GABRA1 (0.41) | MAPTKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL5672882 | 0.79 | SMN1; SMN2 (0.35) | TP53MAPTSLC16A3SLC16A1MCTS1 | |
| SCHEMBL5113620 | 0.78 | MRGPRX4 (0.48) | TP53MAPTMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE46024-E1 | Thyroid hormone analogs | HOFFMANN-LA ROCHE INC. (US) | 2016-06-07 | — | — | US | disclosed |