Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 2/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19803950 | 0.85 | HTR2A (0.37) | HTR2AALDH1A1MAPK1L3MBTL1MGLL | |
| SCHEMBL16847982 | 0.85 | HTR2A (0.37) | HTR2AALDH1A1MAPK1L3MBTL1MGLL | |
| SCHEMBL17803629 | 0.85 | HTR2A (0.37) | HTR2AALDH1A1MAPK1L3MBTL1MGLL | |
| SCHEMBL23020008 | 0.83 | OPRM1 (0.35) | LMNA | |
| SCHEMBL16829392 | 0.82 | HTR2A (0.39) | HTR2AALDH1A1MGLLDPP8DPP9 | |
| SCHEMBL18722888 | 0.80 | HTR2A (0.41) | HTR2AALDH1A1MAPK1L3MBTL1KMT2A | |
| SCHEMBL20830999 | 0.80 | OPRM1 (0.36) | ALDH1A1MAPK1L3MBTL1MGLLKMT2A | |
| SCHEMBL19683911 | 0.80 | OPRM1 (0.36) | ALDH1A1MAPK1L3MBTL1MGLLKMT2A | |
| SCHEMBL21249107 | 0.79 | HTR2A (0.40) | HTR2AALDH1A1MAPK1L3MBTL1KMT2A | |
| SCHEMBL21254302 | 0.79 | HTR2A (0.45) | HTR2AALDH1A1MAPK1L3MBTL1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464280-B1 | SILVESTROL ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | HOFFMANN LA ROCHE (CH) | 2021-10-06 | — | — | EP | disclosed |
| WO-2016090040-A9 | ANTI-STAPHYLOCOCCUS AUREUS ANTIBODY RIFAMYCIN CONJUGATES AND USES THEREOF | GENENTECH, INC. (US) | 2017-06-29 | — | — | WO | disclosed |
| WO-2016090040-A1 | ANTI-STAPHYLOCOCCUS AUREUS ANTIBODY RIFAMYCIN CONJUGATES AND USES THEREOF | GENENTECH, INC. (US) | 2016-06-09 | — | — | WO | disclosed |
| WO-2016090038-A1 | ANTI-STAPHYLOCOCCUS AUREUS ANTIBODY RIFAMYCIN CONJUGATES AND USES THEREOF | GENENTECH, INC. (US) | 2016-06-09 | — | — | WO | disclosed |