Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 20/20 | 0.46 |
| ▸ | BRD4 | O60885 | 4/20 | 0.44 |
| ▸ | EP300 | Q09472 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17809749 | 0.88 | CREBBP (0.47) | CREBBPBRD4 | |
| SCHEMBL17806321 | 0.87 | CREBBP (0.44) | CREBBPBRD4EP300 | |
| SCHEMBL17794572 | 0.83 | CREBBP (0.59) | CREBBPBRD4EP300 | |
| SCHEMBL17809599 | 0.83 | CREBBP (0.44) | CREBBPBRD4EP300 | |
| SCHEMBL17809792 | 0.81 | CYP11B2 (0.39) | — | |
| SCHEMBL17809757 | 0.79 | CREBBP (0.44) | CREBBPBRD4EP300 | |
| SCHEMBL17809617 | 0.77 | CREBBP (0.63) | CREBBPBRD4EP300 | |
| SCHEMBL17809762 | 0.76 | CREBBP (0.43) | CREBBPBRD4EP300 | |
| SCHEMBL17806322 | 0.76 | CREBBP (0.44) | CREBBPBRD4 | |
| SCHEMBL17809601 | 0.74 | CREBBP (0.44) | CREBBPBRD4EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170333406-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-23 | — | — | US | disclosed |
| US-9763922-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2017-09-19 | — | — | US | disclosed |
| US-20160158207-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170333406-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | EP300, HDAC1, HDAC10 | CREBBP 6/4885BRD4 11/4885EP300 1/4885 |
| US-20160158207-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | EP300, HDAC1, HDAC10 | CREBBP 6/4885BRD4 11/4885EP300 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.