Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 6/20 | 0.33 |
| ▸ | RAB9A | P51151 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM5C | P41229 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.33 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.33 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13556188 | 0.79 | APP (0.59) | APPNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL1500181 | 0.78 | PIK3CG (0.55) | APPMCHR1DRD2DRD4DRD3 | |
| SCHEMBL22235439 | 0.78 | MCHR1 (0.41) | APPMCHR1NPC1RAB9AALDH1A1 | |
| SCHEMBL5055929 | 0.78 | APP (0.46) | APPMCHR1NPC1RAB9AALDH1A3 | |
| SCHEMBL1665528 | 0.78 | RAB9A (0.56) | APPMCHR1NPC1RAB9AALDH1A1 | |
| SCHEMBL16739999 | 0.76 | KDM4E (0.49) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL22259100 | 0.75 | MCHR1 (0.48) | APPMCHR1NPC1RAB9AALDH1A1 | |
| SCHEMBL19444520 | 0.75 | RAB9A (0.49) | APPMCHR1NPC1RAB9AALDH1A1 | |
| SCHEMBL25045602 | 0.74 | APP (0.49) | APPDRD2DRD4DRD3NPC1 | |
| SCHEMBL15177306 | 0.72 | APP (0.73) | APPNPC1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365540-B2 | Benzimidazole derivatives as MCH receptor antagonists | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-06-14 | — | — | US | disclosed |