Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.50 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30101423 | 0.98 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2AMITFHTT | |
| SCHEMBL23775098 | 0.95 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2AMITFHTT | |
| SCHEMBL6262165 | 0.89 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2AMITFHTT | |
| SCHEMBL8267685 | 0.81 | ALDH1A1 (0.69) | ALDH1A1KMT2AMITFHTTRAB9A | |
| SCHEMBL8667464 | 0.81 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2AMITFHTT | |
| SCHEMBL6551651 | 0.81 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2AMITFHTT | |
| SCHEMBL6979453 | 0.81 | GAA (0.71) | ALDH1A1MEN1KMT2AMITFHTT | |
| SCHEMBL1205842 | 0.81 | GAA (0.71) | ALDH1A1MEN1KMT2AMITFHTT | |
| SCHEMBL5561079 | 0.81 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2AMITFHTT | |
| SCHEMBL9130301 | 0.81 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2AMITFHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9365511-B2 | Biphenyl-ethyl-pyrrolidine derivatives as histamine H3 receptor modulators for the treatment of cognitive disorders | ARENA PHARMACEUTICALS, INC. (US) | 2016-06-14 | — | — | US | disclosed |
| CN-105263914-A | Biphenyl-ethyl-pyrrolidine derivatives as histamine H3 receptor modulators for the treatment of cognitive disorders | ARENA PHARM INC | 2016-01-20 | — | — | CN | disclosed |