Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 11/20 | 0.63 |
| ▸ | PLK1 | P53350 | 9/20 | 0.63 |
| ▸ | BRDT | Q58F21 | 4/20 | 0.63 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.60 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.60 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.60 |
| ▸ | IGF1R | P08069 | 3/20 | 0.58 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.58 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1781640 | 0.87 | AURKA (0.69) | BRD4PLK1BRDTAURKAAURKB | |
| SCHEMBL1783588 | 0.87 | LRRK2 (0.53) | BRD4PLK1BRDTAURKALRRK2 | |
| SCHEMBL1780091 | 0.83 | TTK (0.57) | BRD4PLK1AURKAIGF1RPTK2 | |
| SCHEMBL5921305 | 0.83 | PLK1 (0.64) | BRD4PLK1BRDTAURKAAURKB | |
| SCHEMBL27947779 | 0.82 | AURKA (0.64) | BRD4PLK1BRDTAURKAAURKB | |
| SCHEMBL4241300 | 0.82 | AURKA (0.64) | BRD4PLK1BRDTAURKAAURKB | |
| SCHEMBL1781068 | 0.82 | TTK (0.76) | AURKAIGF1R | |
| SCHEMBL1782276 | 0.81 | EGFR (0.59) | BRD4AURKALRRK2DCLK1IGF1R | |
| SCHEMBL4234396 | 0.81 | BRD4 (0.59) | BRD4PLK1BRDTAURKAAURKB | |
| SCHEMBL1781156 | 0.80 | TTK (0.70) | AURKAIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110118238-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2011-05-19 | — | — | US | disclosed |
| EP-2212326-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009024824-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118238-A1 | 2-ANILINOPURIN-8-ONES AS INHIBITORS OF TTK/MPS1 FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | BUB1, BUB1B, TTBK1 | BRD4 3407/4885PLK1 7/4885BRDT 1615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.